ENCEPHALITOZOON INTESTINALIS PDF

Encephalitozoon intestinalis is a parasite. It is notable as having one of the smallest genome among known eukaryotic organisms, containing only 2. Recently, Some domestic and wild animals have been found to be naturally infected with E. It causes Gastro-Intestinal tract infection which subsequently leads to diarrhea and circulates to the ocular, genitourinary and respiratory tracts. Research has proven that E. Microsporidia are obligate intracellular opportunistic fungi that cause significant pathology in immunocompromised simply put: having an impaired immune system hosts.

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Despite the fact that many approaches have been developed over years to find efficient and well-tolerated therapeutic regimens for microsporidiosis, the effectiveness of current drugs remains doubtful, and effective drugs against specific targets are still scarce. The present study is the first that was designed to evaluate the potency of auranofin, an anti-rheumatoid FDA approved drug, against intestinal Encephalitozoon intestinalis.

Evaluation of the drug was achieved through counting of fecal and intestinal spores, studying the intestinal histopathological changes, measuring of intestinal hydrogen peroxide level, and post therapy follow-up of mice for 2 weeks for detection of relapse.

Results showed that auranofin has promising anti-microsporidia potential. It showed a promising efficacy in mice experimentally infected with E. It has revealed an obvious reduction in fecal spore shedding and intestinal tissue spore load, amelioration of intestinal tissue pathological changes, and improvement of the local inflammatory infiltration without significant changes in hydrogen peroxide level.

Interestingly, auranofin prevented the relapse of infection. Most users should sign in with their email address.

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Article Contents Abstract. Funding sources. Oxford Academic. Google Scholar. M R Gaafar. To whom correspondence should be addressed. Tel: ; Fax: ; E-mail: drmahagaafar yahoo. M M Gomaa. S I Khedr. S N El Achy. Select Format Select format. Permissions Icon Permissions. Abstract Despite the fact that many approaches have been developed over years to find efficient and well-tolerated therapeutic regimens for microsporidiosis, the effectiveness of current drugs remains doubtful, and effective drugs against specific targets are still scarce.

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DOUG DUBOSQUE PDF

Microsporidiosis

Despite the fact that many approaches have been developed over years to find efficient and well-tolerated therapeutic regimens for microsporidiosis, the effectiveness of current drugs remains doubtful, and effective drugs against specific targets are still scarce. The present study is the first that was designed to evaluate the potency of auranofin, an anti-rheumatoid FDA approved drug, against intestinal Encephalitozoon intestinalis. Evaluation of the drug was achieved through counting of fecal and intestinal spores, studying the intestinal histopathological changes, measuring of intestinal hydrogen peroxide level, and post therapy follow-up of mice for 2 weeks for detection of relapse. Results showed that auranofin has promising anti-microsporidia potential. It showed a promising efficacy in mice experimentally infected with E. It has revealed an obvious reduction in fecal spore shedding and intestinal tissue spore load, amelioration of intestinal tissue pathological changes, and improvement of the local inflammatory infiltration without significant changes in hydrogen peroxide level.

MANIFIESTO ZAPATISTA EN NAHUATL PDF

Microsporidia are a group of intracellular pathogens causing self-limited and severe diseases in immunocompetent and immunocompromised individuals, respectively. Ei -exposed DC cultures consisted of immature infected and mature bystander DC, as assessed by MHC class II and costimulatory molecules expression, suggesting that intracellular Ei spores deliver inhibitory signals in DC. Neutralization experiments demonstrated that this inhibitory effect is ILdependent. Altogether this investigation reveals a novel potential mechanism of immune escape of microsporidian parasites through the modulation of DC differentiation and maturation. The phylum Microsporidia comprises a numerous group of obligate intracellular fungal parasites that infect a wide range of invertebrate and vertebrate animals. Moreover, microsporidia are also common colonizers of immune-competent individuals in which self-limited or asymptomatic infections are observed Ghosh and Weiss,

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