Metformin, the only biguanide currently available commercially, is more than an oral hypoglycemic agent, it is also a glycoregulatory drug. The molecular features of its mechanism of action are not well defined, but its main action is based on an increase of insulin sensitivity in the liver and on facilitating glucose transport in situations of hyperglycemia and insulin resistance. Metformin is currently the initial drug of choice in patients with type 2 diabetes mellitus with and without excess weight. Its use in combination with oral antidiabetic agents sulfonylureas, meglitinides, glitazones, alpha-glucosidase inhibitors and insulin improve its therapeutic profile. Clinically, its positive effect on glycemic control is complemented by other actions such as avoidance of weight gain and improvement of lipid and cardiometabolic risk. The efficacy of metformin has been demonstrated in studies of diabetes mellitus prevention and other indications associated with insulin resistance..

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Generally, an eBook can be downloaded in five minutes or less Browse by Genre Available eBooks Show More. Noeyes Arvilla. Medyta Garcia. Alba Marisol Zepeda Garcia at clinica quirurgica del desierto. No Downloads. Views Total views. Actions Shares. Embeds 0 No embeds. No notes for slide. Teorico de Insulina e Hipoglucemiantes 1. Debut con sindromes agudos: DM tipo 1 4. Farmacocinetica A Administracion por via subcutanea abdomen, brazos y region anterior del muslo.

D Libre en plasma. M Vida media min. E renal. Farmacocinetica A Administracion por via oral. D Alta union a proteinas plasmaticas. M Vida media 1 Generacion: 30 horas aprox. Vida media 2 Generacion: 5 horas aprox. Biotransformacion hepatica. E Renal Se unen a un receptor diferente a las sulfonilureas. You just clipped your first slide! Clipping is a handy way to collect important slides you want to go back to later.

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Profesora Titular. Facultad de Medicina, Universidad de Los Andes. Existen dos clases de agentes sensibilizadores de insulina: las biguanidas metformina y las glitazonas rosiglitazona y pioglitazona. El tratamiento continuo durante el embarazo disminuye la necesidad de iniciar insulino terapia en los casos con diabetes gestacional Pacientes con irregularidades menstruales que no desean tomar contraceptivos orales o que tengan contraindicaciones para el uso de estos agentes. En pacientes con resistencia ovulatoria al citrato de clomifeno.





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